ZEBUTRIM INJECTION 30 ML

• Trimethoprim (TMP) – 80 mg

• Sulfamethoxazole (SMX) – 400 mg

The combination (often written as TMP-SMX or Co-trimoxazole) is used in veterinary medicine for its broad-spectrum antibacterial activity.

Pharmacological Class

• Antibacterial (sulfonamide + dihydrofolate reductase inhibitor)

• Bactericidal effect when combined (synergistic action)

⚙️ Mechanism of Action

• Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid (a folate precursor).

• Trimethoprim inhibits dihydrofolate reductase, blocking the conversion to tetrahydrofolic acid.

• The combination sequentially blocks two steps in the folic acid pathway → inhibits bacterial DNA synthesis.

Indications (Typical Veterinary Uses)

Effective against a wide range of Gram-positive and Gram-negative bacteria, commonly used for:

• Respiratory infections (pneumonia, bronchitis)

• Urinary tract infections

• Enteric (gastrointestinal) infections

• Wound infections, abscesses

• Mastitis

• Metritis

• Prostate and skin infections

Used in cattle, sheep, goats, pigs, horses, dogs, and cats, depending on the formulation and veterinary guidance.

Dosage and Administration

Always follow veterinary prescription and product label — dosage may vary by formulation and species.

• Usual dose (IM or IV):
  Trimethoprim 3–5 mg/kg + Sulfamethoxazole 15–25 mg/kg
  (equivalent to ~1 mL per 16–20 kg body weight for the 80/400 mg/mL formulation)

• Frequency: Once or twice daily (every 12–24 hours)

• Duration: 3–7 days, or as directed by the veterinarian

⚠️ Contraindications / Precautions

• Do not use in animals with:

  • Known hypersensitivity to sulfonamides or trimethoprim

  • Severe liver or kidney impairment

• Use with caution in dehydrated animals.

• Ensure adequate hydration during treatment.

Possible Adverse Effects

• Local pain/swelling at injection site

• Gastrointestinal upset (vomiting, diarrhea in small animals)

• Allergic reactions (skin rash, fever)

• Blood dyscrasias (rare with prolonged use)

Storage

• Store below 25°C, protected from light.

• Do not freeze.

• Use within the manufacturer’s recommended period after opening.