BOVICORT-I INJECTION 100 ML

Each ml of Isoflupredone Acetate Injectable Suspension Contains:
Isoflupredone Acetate USP .......... 2 mg
Water for injection IP .................... q.s to 1 ml

Isoflupredone Acetate Injectable Suspension is intended for intramuscular or intra-synovial injection in animals. It is indicated through intramuscular route in situations requiring glucocorticoid, anti-inflammatory, and/or supportive effect while the intrasynovial route is indicated in joint inflammation, tendonitis & bursitis.

INDICATIONS:

1. Bovine ketosis

2. Parturient paresis (supportive stress therapy for milk fever-therapy)

3. Alleviating pain & lameness associated with generalized & acute localized arthritic conditions

4. Inflammatory conditions such as laminitis, rheumatoid & traumatic arthritis, tendonitis, periostitis, tenosynovitis, bursitis & myositis

5. Generalized muscular soreness, stiffness, depression & anorexia resulting from overwork, shipping, unusual physical exertion etc

6. Various allergic conditions like anaphylactic reaction, dermatitis, conjunctivitis, eczema

7. Acute hypersensitive reaction resulting from treatment with desensitizing drug or exposure to other allergenic agents.

8. Overwhelming infection with severe toxicity such as mastitis, pneumonia and in other similar infectious conditions, as a supportive therapy when seen before complete recovery

9. Shock like states occurring in association with severe injury, trauma, emergency surgery & elective surgery in poor surgical risks along with standard methods of combating shock

10. Other indication: Exhaustion following surgery or dystocia, retained placenta, inflammatory ocular conditions, snakebite and other stressful conditions

Isoflupredone is an effective and valuable treatment for the endocrine and metabolic imbalance of primary bovine ketosis. Isoflupredone is nearly 100 times more gluconeogenic than prednisolone, 50 times that of hydrocortisone & 67 times that of cortisone as measured by liver glycogen deposition in rats.

In animal with overwhelmingly severe infections for which specific antibacterial therapy is available (e.g. Pneumonia, peritonitis, endometritis, septic mastitis), Isoflupredone therapy may be used as a supportive therapy.

UNIQUE FEATURES

1. Safe, no effect on lactation

2. No milk withholding required

3. Safe in pregnancy, does not induce abortion

4. Increases glucose levels quickly

5. 10 times more potent than prednisolone

6. Long-acting effect — up to 48 hours of gluconeogenic activity

3S EFFECT OF ISOFLUPREDONE ACETATE INJECTABLE SUSPENSION

Safer

• Safe in pregnancy / Non-teratogenic

• No effect on lactation (does not decrease milk production usually associated with steroids)

• Less immuno-suppression

Swifter

• Blood glucose level returns to normal within 8 to 24 hours (in cows suffering from ketosis-stress of parturition & high milk production which predisposes to this condition)

Stronger

• The glucocorticoid activity is nearly 10 times more than that of Prednisolone (The hyperglycemic effect in both normal & ketotic cattle)

ADMINISTRATION

By deep intramuscular injection for systemic effect, or into joint cavity, tendon sheath or bursa for local effect.

DOSAGE

Cattle
5 to 10 ml of Isoflupredone Acetate Injectable Suspension (10 to 20 mg of Isoflupredone Acetate) according to the size of animal and severity of the condition. The dose may be repeated in 12 to 24 hours, if indicated.

Horses
3 to 10 ml of Isoflupredone Acetate Injectable Suspension (5 to 20 mg Isoflupredone Acetate)

Small animals
0.1 ml of Isoflupredone Acetate Injectable Suspension (0.2 mg of Isoflupredone Acetate) per kg of B.W.